Valspodar 是一種 p-糖蛋白 (P-gp) 抑制劑，被廣泛用作克服多藥耐藥性調節劑。

MCE (MedChemExpress) 是全球領先的科研化學品和生物活性化合物供應商，總部位于美國新澤西。MCE 的產品范圍覆蓋各種抑制劑、激動劑和化合物庫。

Valspodar 是一種 p-糖蛋白 (P-gp) 抑制劑，被廣泛用作克服多藥耐藥性調節劑。
Valspodar產品描述：Valspodar is a P-glycoprotein (P-gp) inhibitor widely used as overcoming multidrug resistance modulator.
In Vitro：Valspodar (PSC 833) has no cytotoxicity effects at up to the concentration of 0.75 μg/mL. Valspodar (0.25, 0.5 and 0.75 μg/mL) and DOX-L are added to the DOX resistant cells, and cell kill efficacy of MDR cell type increases significantly when valspodar is administered alongside DOX-L. Valspodar (0.5 and 0.75 μg/mL), in combination with all concentrations of DOX, are most toxic and kill more than 70% of the resistant cells^[1]. Pretreatment with PSC833 decreases the IC₅₀ value of mitoxantrone in MDA-MB-435mdr cells to 0.4±0.02 μM in MDR cells and almost completely reverses the resistance of MDR cells to mitoxantrone^[3].
In Vivo：valspodar (10 mg/kg, o.p.) exhibits minimal blood-cell partitioning as reflected in its low mean blood-to-plasma ratio of approximately 0.52. Valspodar displays properties of slow clearance and a large volume of distribution. Valspodar shows properties of low hepatic extraction and wide distribution, similar to that of its structural analogue cyclosporine A^[2]. Preadministration of PSC833 to mice increases mitoxantrone fluorescent intensity in MDR tumor to 94% of that in the wild-type tumors^[3].


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MCE 對每批產品都進行嚴格的LCMS和NMR檢驗，其產品已被近萬名客戶廣泛使用并發表大量文章、；
MCE 定期增加各領域熱門抑制劑、激動劑，不斷擴增已有化合物庫，以滿足新的科研需求；
數千種產品在上海有充足備貨，24-48小時內送達客戶；
大量產品提供試用裝； 已為多個知名企業、院校構建各種定制型化合物庫。

Purity:98%
MWt:1214.6220
Formula:C63H111N11O12
SMILES:O=C([C@H](C(C)C)N(C)C([C@H](CC(C)C)N(C)C([C@H](CC(C)C)N(C)C([C@@H](C)NC([C@H](C)NC([C@H](CC(C)C)N(C)C([C@H](C(C)C)NC([C@H](CC(C)C)N(C)C(CN(C)C([C@H](C(C)C)N1)=O)=O)=O)=O)=O)=O)=O)=O)=O)N(C)[C@@H](C([C@H](C)C/C=C/C)=O)C1=O
Pathway:Membrane Transporter/Ion Channel;
Mechanisms:P-glycoprotein;
Research Area:Cancer




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