Nigericin sodium salt 是從吸水鏈霉菌中得到的一種抗生素，作為 H+，K+ 和 Pb2+ 離子載體起作用。

MCE (MedChemExpress) 是全球領(lǐng)先的科研化學(xué)品和生物活性化合物供應(yīng)商，總部位于美國新澤西。MCE 的產(chǎn)品范圍覆蓋各種抑制劑、激動(dòng)劑和化合物庫。

Nigericin sodium salt 是從吸水鏈霉菌中得到的一種抗生素，作為 H⁺，K⁺ 和 Pb²⁺ 離子載體起作用。
Nigericin sodium salt產(chǎn)品描述：Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus that works by acting as an H⁺, K⁺, and Pb²⁺ ionophore.
In Vitro:Nigericin (0.1 μM) decreases inhibits proliferation and clonogenicity of H460 lung cancer cells in a dose dependent manner. Nigericin inhibits migration and invasion of H460 lung cancer cells^[1]. Nigericin (0.1-10 nM) has apparently a dual effect on cell volume, that is a shrinking effect at lower Nigericin concentrations and a swelling effect at higher concentrations. Nigericin (0.1-1 nM) significantly decreases cytosolic pH (pHi), and slightly increases the pHi at 5 and 10 nM^[2]. Nigericin exhibits higher toxicity on S18 cells than S26 cells, with IC₅₀ of 2.03±0.55 μM and 4.77±2.35 μM, respectively. Nigericin can selectively kill cancer stem cells in NPC in vitro. Nigericin dramatically reduces the migration ability of S18 and HONE-1 cells^[3]. Nigericin exhibits gteat toxicity for the HT29 and SW116 cell line with IC₅₀ of 12.92±0.25 μmol and 15.86±0.18 μmol. Nigericin also shows a decreased ability to form colonies under anchorage-independent conditions in a standard soft agar assay^[4].
In Vivo: Milrinone (1 μg/kg/min, i.v.) significantly reduces PAP, PVR (?18.96 ± 1.7%), and LAP (?26.03 ± 2.3%) in congestive heart failure (CHF) rats. Milrinone (1 mg/mL, inhalation) results in a near-maximal reduction of PAP without significant effects on AP, decreases pulmonary artery pressure similarly in a larger collective of CHF rats. Milrinone Ngericin (4 mg/kg, i.p.) significantly reduces tumor growth and acts synergistically with the chemotherapeutic agent DDP, as shown by the tumor volumes. Nigericin markedly decreases Bmi-1 in vivo. Overexpression of Bmi-1 partially restores CSC content and metastatic ability of NPC cells under Nigericin treatment. The downregulation of Bmi-1 may be involved in the inhibitory effect of Nigericin on CSCs in NPC^[3].


公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動(dòng)劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設(shè)有歐洲區(qū)子公司和區(qū)總代理，營銷網(wǎng)點(diǎn)遍及20多個(gè)地區(qū)。MCE經(jīng)過多年努力已成為生物活性小分子領(lǐng)域的供應(yīng)商， 產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個(gè)熱門研究領(lǐng)域，PI3K、MAPK等近千個(gè)細(xì)分靶點(diǎn)，超過4000個(gè)活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時(shí)提供從毫克到千克的專業(yè)定制合成服務(wù)。
MCE 對(duì)每批產(chǎn)品都進(jìn)行嚴(yán)格的LCMS和NMR檢驗(yàn)，其產(chǎn)品已被近萬名客戶廣泛使用并發(fā)表大量文章、；
MCE 定期增加各領(lǐng)域熱門抑制劑、激動(dòng)劑，不斷擴(kuò)增已有化合物庫，以滿足新的科研需求；
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大量產(chǎn)品提供試用裝； 已為多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫。

Purity:98%
MWt:746.9432
Formula:C40H67NaO11
SMILES:C[C@H]1[C@](O[C@@H]2C[C@](CC[C@@H]3C)([H])O[C@@]3([H])[C@@H](C)C([O-])=O)([C@@H]([C@H](OC)C2)C)O[C@](C)([C@]4([H])O[C@](C)([C@]5([H])O[C@]([C@@]([C@H](C[C@H]6C)C)([H])O[C@@]6(O)CO)([H])C[C@@H]5C)CC4)C1.[Na+]
Pathway:Membrane Transporter/Ion Channel;
Mechanisms:Potassium Channel;
Research Area:Cancer



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