Squalamine(MSI-1256)是具有廣譜抗病毒活性化的化合物。

MCE (MedChemExpress) 是全球領先的科研化學品和生物活性化合物供應商，總部位于美國新澤西。MCE 的產品范圍覆蓋各種抑制劑、激動劑和化合物庫。

Squalamine(MSI-1256)是具有廣譜抗病毒活性化的化合物。
Squalamine(MSI-1256)產品描述：Squalamine(MSI-1256) is an aminosterol compound with potent broad spectrum antiviral activity. IC50 value: Target: in vitro: squalamine can strongly displace membrane-bound cationic proteins such as Rac1, a ρ-GTPase recruited to the inner leaflet of the eukaryotic cytoplasmic membrane for the actin remodeling necessary for endocytosis. At concentrations between 20 and 60 μg/mL, squalamine has been shown to inhibit a broad array of growth factor-induced, actin-dependent responses in endothelial cells, including cell migration, cell division, and vascular tube formation in a 3D matrix [1]. Squalamine effectively inhibited HBV replication in human primary hepatocytes when added either during the initial exposure of virus to the cells or at 24 h after infection. A similar study was performed to evaluate the effect of squalamine on the replication of HDV. Squalamine was introduced at 20 μg/mL during HDV exposure, and the effects were measured at day 7 when total RNA was extracted and assayed for HDV RNA sequences [1]. in vivo: one time daily treatment with squalamine (15 or 30 mg/kg per d s.c.) was started beginning on day 1 or 2 after viral administration and continuing until day 8 or 9, respectively. Survival was monitored, and animals that remained alive by day 21 were considered cured [1].

公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設有歐洲區子公司和區總代理，營銷網點遍及20多個地區。MCE經過多年努力已成為生物活性小分子領域的供應商， 產品涵蓋癌癥、神經科學、抗感染、表觀遺傳學等20個熱門研究領域，PI3K、MAPK等近千個細分靶點，超過4000個活性小分子化合物現貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時提供從毫克到千克的專業定制合成服務。
MCE 對每批產品都進行嚴格的LCMS和NMR檢驗，其產品已被近萬名客戶廣泛使用并發表大量文章、；
MCE 定期增加各領域熱門抑制劑、激動劑，不斷擴增已有化合物庫，以滿足新的科研需求；
數千種產品在上海有充足備貨，24-48小時內送達客戶；
大量產品提供試用裝； 已為多個知名企業、院校構建各種定制型化合物庫。

Purity:98%
MWt:627.96
Formula:C34H65N3O5S
SMILES:C[C@@]12[C@](C[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@@H](CC[C@H](C(C)C)OS(=O)(O)=O)C)([H])C[C@@H](NCCCNCCCCN)CC1
Pathway:Anti-infection;
Mechanisms:Bacterial; HBV;
Research Area:Infection




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