產品編號: KMP2236產品名稱: Human Biotinylated CD28 Protein, Fc Tag, Avi Tag中文名稱: 生物素化重組人CD28蛋白中文全稱: 生物素化重組人T細胞特異性表面糖蛋白CD28蛋白

卡梅德生物科技（天津）有限公司作為高新技術企業，專注于為全球科學家和研究機構提供天然蛋白提取與發酵、重組蛋白定制表達服務，單、多克隆抗體開發，噬菌體文庫構建與篩選服務；同時，基于我公司成熟的五大核心技術服務平臺，成功研發了眾多用于科學研究的重組蛋白、抗體、抗體藥物靶點蛋白、工業酶、診斷原料等相關試劑

產品編號: KMP2236
產品名稱: Human Biotinylated CD28 Protein, Fc Tag, Avi Tag
中文名稱: 生物素化重組人CD28蛋白
中文全稱: 生物素化重組人T細胞特異性表面糖蛋白CD28蛋白
關鍵詞: T細胞特異性表面糖蛋白CD28, CD28, CD28 molecule, Tp44, MGC138290, CD28 antigen, CD28 antigen(Tp44), T-cell-specific surface glycoprotein, Human Biotinylated CD28 Protein, Fc Tag, Avi Tag, Recombinant Protein, KMP2236，生物素化重組人CD28蛋白
物種: Human
宿主: HEK293 Cells
規格: 50ug, 100ug, 200ug
純化方式: Affinity purification
純度: >95% as determined by SDS-PAGE
內毒素水平: <1.0 EU/ug determined by the LAL method
緩沖體系: 20mM Tris-HCl, 150mM NaCl, pH8.0
Uniprot: P10747
產品圖片：
功能: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933).
Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).
產品背景: T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type(immunoglobulin-like) domain. It belongs to the immunoglobulin(Ig) superfamily. CD28 is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 co-stimulation is necessary for CD4 positive T-cell proliferation and survival, interleukin-2 production, and T-helper type-2 development. Human post-thymic regulatory T cells require CD28 co-stimulation to expand and maintain potent suppressive function in vivo. Apoptosis plays a key role in the age-related decline of CD28 expression and in immunosenescence. CD28 is the receptor for CD80(B7.1) and CD86(B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells(APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
保存條件: Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
運輸條件: In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
說明: This product is for research use only.
參考文獻: 1.J. Exp. Med. 199:1025-1031 (2004)
2.J. Immunol. 156:3133-3140
生物素化重組人CD28蛋白

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