產品簡介
Recombinant Human TGF-3 (E.coli derived)產品編號:100-36E別名:Transforming Growth Factor-3描述:The three mammalian isof
公司簡介
北京杰輝博高生物技術有限公司依托國家重點實驗室建立,是由具有資深生命科學、生物技術背景及留學歸國人員共同創辦的高新技術企業。
公司專業經營生物科學領域的實驗儀器、研究試劑和實驗室耗材,致力于向國內外生物科學研究人員提供一流的服務。
目前,公司推出的產品涵蓋了生物化學、分子生物學、免疫學、細胞生物學等相關領域,因優質穩定、性價比高等特點在廣大科研機構、研究院校及相關企業中贏得了良好的聲譽,從而建立了立體的營銷網絡和擁有廣泛的客戶資源。
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產品說明
Recombinant Human TGF-β3 (E.coli derived)
產品編號:
100-36E
別名:
Transforming Growth Factor-β3
描述:
The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. The physiological role of TGF-β3 is still unknown but its expression pattern suggests a role in the regulation of certain development processes. Recombinant human TGF-β3 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.
氨基酸序列:
ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS
來源:
E.coli
純度:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
生物活性:
The ED50 was determined by TGF-β3’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥2 x 107 units/mg.
交叉反應:
Cow, Dog, Mouse, Pig, Rat
研究領域:
 |
血管生成/ 心血管 |
 |
細胞凋亡 |
 |
癌癥 |
 |
免疫系統 |
 |
炎癥 |
 |
增殖 |
 |
干細胞及分化 |
 |
TGF超家族 |
 |
創傷修復 |
|
原產國:
USA
僅用于研究。不適用于診斷或治療。
聯系:
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