英文名稱    phospho-c-Jun (Thr91)    
中文名稱    磷酸化原癌基因c-Jun抗體         
產品類型    磷酸化抗體     
研究領域    腫瘤  細胞生物  免疫學  信號轉導  轉錄調節因子  表觀遺傳學      
抗體來源    Rabbit    
克隆類型    Polyclonal    
交叉反應    Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep,     
產品應用    WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg/Test IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    
分 子 量    43kDa    
細胞定位    細胞核     
性    狀    Lyophilized or Liquid    
濃    度    1mg/ml    
免 疫 原    KLH conjugated Synthesised phosphopeptide derived from human c-Jun around the phosphorylation site of Thr91:TT(p-T)PT     
亞    型    IgG    
純化方法    affinity purified by Protein A    
儲 存 液    0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.    
保存條件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    
PubMed    PubMed    


產品介紹    The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. cJun (previously known as the Fos binding protein p39) and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations and deletions in human malignancies.
   
C-jun(oncoprotein C-jun：active protein 1)基因與鳥類肉瘤病毒17的轉化基因具有同源性，是早期應答基因家族成員之一。主要用于各種惡性腫瘤的研究。 C-jun又稱：應激活化蛋白激酶。