Ketanserin74050-98-9酮色林,凱他色林赫澎生物說明書
發布時間：2016-09-13瀏覽次數：1311返回列表
| 酮色林,凱他色林 分子式：C22H22FN3O3 分子量：395.43產品描述 Ketanserin (Vulketan Gel) 是特異性的5-HT2A 5-羥色胺受體拮抗劑，作用于大鼠和人類5-HT2A，Ki為2.5 nM。 靶點 生物活性 Ketanserin (Vulketan Gel) is specific 5-HT2A serotonin receptor antagonist with a Ki of 2.5 nM for rat and human 5-HT2A. Ketanserin (Vulketan Gel) is a drug with affinity for multiple G protein-coupled receptors. Ketanserin ( Vulketan Gel) inhibits rat and human 5-HT2C with Ki of 50 and100 nM, respectively and has higher affinity binding for alpha-1 adrenergic (Ki = ~ 40 nM) and Histamine H1 (Ki = 2 nM). Ketanserin (Vulketan Gel) can also be used to discriminate between 5-HT1D and 5-HT1B receptor subtypes. Ketanserin (Vulketan Gel) has antihypertensive properties. Ketanserin (Vulketan Gel) also reduces platelet aggregation produced by serotonin. Ketanserin also has high affinity for alpha-1 adrenergic receptors, and very high affinity for histamine H1 receptors. Ketanserin (Vulketan Gel) was shown to reduce the severity and frequency of the vasospasm in Raynaud’s phenomenon. 溶解性 DMSO 2 mg/mL，水 <1 mg/mL，乙醇 <1 mg/mL 穩定性 2年 -20°C粉狀，6月-80°C溶于DMSO |
