我公司致力于為客戶提供高純度、低成本的活性重組蛋白，包括重組人信號素在內的各類受體、細胞因子、生長因子、轉錄因子、激素、酶、毒性蛋白、病毒抗原等。...

特別提示：包括重組人信號素(Semaphorin )(Sema)在內，本公司的所有產品僅可用于科研實驗，嚴禁用于臨床醫療及其他非科研用途！

產品名稱：重組人信號素(Semaphorin )(Sema)
英文名稱：Recombinant Human Semaphorin
產品貨號：JN0591
產品規格：10μg|50μg|500μg|1mg

本品由我們的哺乳動物細胞表達系統制備而成，目的基因編碼的Glu23-Thr765在C端含有His標簽。

Semaphorin 質量控制：＞95%(還原性SDS-PAGE)

Semaphorin 制劑：凍干品

Semaphorin 保存：
凍干蛋白置于-20℃以下可長期保存，室溫條件下可穩定保存3周。
復溶蛋白溶液可在4～7℃保存2～7天，可分裝后置于-20℃保存三個月。

Semaphorin 復溶：
打開試劑管前請先離心。
復溶濃度推薦大于100 μg/ml。
凍干蛋白請溶于ddH2O。
復溶后，請根據用量分裝凍存，避免反復凍融。

關于Semaphorin ：
Semaphorin- (SEMA) is a member of the Semaphorin family of axon guidance molecules. SEMA is a 140 kDa protein. Class 5 Semaphorins are type I transmembrane glycoproteins with an N- terminal Sema domain and multiple juxtamembrane type 1 Thrombospondin (TSP) repeats within their extracellular domains. SEMA is expressed in neuroepithelial cells surrounding retinal axons, oligodendrocytes, the base of limb buds, the mesoderm surrounding cranial vessels , and the cardiac atrial septum and endocardial cushions, Human SEMA cDNA encodes a signal sequence, a extracellular domain (ECD), a transmembrane sequence and an cytoplasmic portion. SEMA mutations have been implicated in the genetic syndrome,cri-du-chat,while some polymorphisms may increase risk for neurodegenerative diseases such as Parkinson. The expression of SEMA may be upregulated in metastatic cancer cells and downregulated in autism.

根據您的關注的重組人信號素(Semaphorin )(Sema)，重組Sema，重組人Sema，重組人信號素，rSema，Recombinant Human Semaphorin ，rhSema，重組人Semaphorin ，重組信號素，重組Semaphorin ，您可能還對以下產品有需求：

貨號	名稱	規格
JN0227	重組人LR3-IGF1	10μg|50μg|500μg|1mg
JN0235	重組人VEGFD(血管內皮生長因子D)(帶His標簽)	10μg|50μg|500μg|1mg
JN0378	重組人白介素IL-13(白細胞介素13)	10μg|50μg|500μg|1mg
JN0472	重組小鼠TNFRSF1B	10μg|50μg|500μg|1mg
JN0497	重組小鼠TL1A(TNFSF15)	10μg|50μg|500μg|1mg
JN2000	重組人γ谷氨酰氨環化轉移酶(GGACT)	10μg|50μg|500μg|1mg

關注重組人信號素(Semaphorin )(Sema)，重組Sema，重組人Sema，重組人信號素，rSema，Recombinant Human Semaphorin ，rhSema，重組人Semaphorin ，重組信號素，重組Semaphorin 的同時，為您推薦更多您可能感興趣的產品：



名稱：重組人白介素IL-36α(白細胞介素36α)
貨號：JN0352
規格：10μg|50μg|500μg|1mg
本品由我們的大腸桿菌表達系統制備，目的基因編碼的Met1-Phe158表達純化而來。

IL-36 alpha/IL-1F6質量控制：＞95%(還原性SDS-PAGE)。

IL-36 alpha/IL-1F6制劑：凍干品

IL-36 alpha/IL-1F6保存：
凍干蛋白可在-20℃長期保存，室溫也可穩定保存3周。
復溶蛋白溶液可在4～7℃保存2～7天。
復溶后建議分裝凍存在-20℃，可保存3個月，應避免反復凍融。

IL-36 alpha/IL-1F6復溶：
1、試劑開蓋前請先離心。
2、復溶濃度應大于100 μg/ml.
3、凍干蛋白溶于ddH2O中
4、復溶后根據使用量分裝保存，避免反復凍融。

關于IL-36 alpha/IL-1F6：
Human Interleukin-36α (IL-36α) is a secreted cytokine that belongs to the Interleukin 1 cytokine family. IL-36α is expressed in the immune system and the fetal brain, but not in other tissues or multiple hematopoietic cell lines. IL-36α is the only IL-1 family member found to be expressed on T-cells. IL-36α and IL-1F8 are involved in the regulation of adipose tissue gene expression. importantly, IL-36α inhibits PPARγ expression, which may lead to a reduction in adipocyte differentiation suggesting metabolic effects of this cytokine. IL-36α, along with IL-1F8 and IL-1F9, has been shown to act as an agonist by activating the pathway involving NFκB and MAPK in an IL-1Rrp2 dependent manner. This suggest that IL-36α may signal in a similar fashion to IL-1 and IL-18 in having a binding receptor which upon ligation, recruits a second receptor as a signaling component, forming an active heterodimeric receptor complex.

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